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KMID : 0381120090310050377
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Genes and Genomics
2009 Volume.31 No. 5 p.377 ~ p.385
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Polymorphisms of Alcohol Metabolizing Enzyme and Cytochrome P4502E1 Genes in Mongolian Population
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Kim Ki-Woong
Heo Kyung-Hwa
Won Yong-Lim
Bayanbileg Shinetugs
Tserenkhuu Lkhagwasuren
Chang Sung-Keun
Paik Sang-Gi
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Abstract
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Although the genetic polymorphism of the alcohol-metabolizing enzymes was extensively studied at the molecular level by many investigators, the genetic polymorphism studies for ethanolmetabolizing enzymes in Mongolians are very rare. The present study was therefore performed to determine the genetic distribution of various forms of alcohol-metabolizing enzymes such as alcohol dehydrogenase 2 (ADH2, currently accepted nomenclature ADH1B), ADH3 (ADH1C), aldehyde dehydrogenase 2 (ALDH2) and cytochrome P4502E1 (CYP2E1) in 300 healthy Mongolian males. Genetic polymorphisms were determined by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) methods. The allele frequencies of ADH2 *1 and ADH2 *2 were 0.24 and 0.76; ADH3 *1 and ADH3 *2 were 0.92 and 0.08; ALDH2 *1 and ALDH2 *2 were 0.96 and 0.04; and CYP2E1 *C and CYP2E1 *D were 0.15 and 0.85, respectively. Compared to the results reported by other investigators, the allele frequencies of ALDH2 *2 and CYP2E1 *C among Mongolian subjects were much lower than among East Asians (Korean, Japanese, and/or Han-Chinese), while those of ADH2 and ADH3 were more similar. Interestingly, this study shows that the ineffective ALDH2 gene (ALDH2*2 allele) among Mongolians is not as common as among East Asians.
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KEYWORD
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ADH2 (ADH1B), ADH3 (ADH1C), ALDH2, CYP2E1, genetic polymorphism, Mongolian
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